Treatment For Damaged Hearts Could Be Enhanced By Chymase Inhibitors

Millions of patients with high blood pressure and heart failure take a class of drugs known as ACE (angiotensin-converting enzyme) inhibitors

These drugs prevent the body from processing angiotensin II, a hormone that constricts blood vessels.

Scientists at Emory University, University of Alabama, Birmingham, and Fukuoka University in Japan have shown that another enzyme present in the heart called chymase is also capable of processing angiotensin II. Adding drugs that interfere with chymase to ACE inhibitors significantly boosted recovery of heart function in animals after heart attack, the researchers found.

The results, to be published in the April 2010 issue of the Journal of Clinical Investigation, could lead to improved treatments for people with high blood pressure, heart failure and other conditions.

(Medical News Today)

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