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Picking the right virus candidate for gene therapy
Viruses often get bad press. Likened to Trojan horses they are often associated with disease. But, i t is precisely because of their infectious nature that they can potentially be used as gene vectors - which are vehicles loaded with good copies of malfunctioning genes - and delivered to cells.
Healing bone defects using regenerative medicine
Bone is one of the most frequently transplanted tissues. And the demand is rising. Transplants treat large defects like those caused by trauma, complicated fractures, tumour resection or osteoporosis. ...
Physical work, not the main cause of intervertebral disc degeneration
Even if you do not suffer from pain in the intervertebral discs in your lower back, it is a sure bet that you know someone who does. Yet, surprisingly little is known about what causes this disc degeneration .
Mapping proteins in space and time within cells
The human genome and those of several other organisms have been mapped. But it is proteins that perform the majority of biological functions within every organism .
Peering down protein-DNA interactions to better understand how genes work
Almost every one of our cells has an entire copy of our genome. But only differing subsets of genes are active and expressed in any given cell. Epigenetics is the study of how the activity of our genes is controlled and regulated .
Parasite surveillance to support policy against drug resistance
Leishmaniasis is a tropical disease known in Europe because it affects dogs. It is caused by the Leishmania parasite carried by sandflies . However, several types of the parasite also affect humans in several regions in the world.
New therapy against rare gene defects
European scientists set up new therapeutic approaches to tackle specific Lysosomal Storage Disorders: a new drug combination and enzyme replacement therapy against Pompe disease and gene therapy against MPS V I (Mucopolysaccharidosis VI).
Better diagnostics for thrombosis are a matter of resources
Cost-effectiveness is paramount for any new medical technology. If pharmaceutical companies do not see a profit, new drugs will never see the light of day.
Advances in Treating Huntington’s Disease
Juliet Ross is suffering from Huntington’s Disease, a rare neurological disorder that affects one in 10.000 people. Due to a genetic defect, her body produces a toxic protein that damages neurons in her brain .
Fighting superbugs
November 18 th is the annual European Antibiotic Awareness Day . Its purpose is to highlight the increase of bacterial resistance to antibiotics on the continent .
Anti-allergy GM apples
Peanut, egg and soy are more common food known to trigger an allergic reaction, a problem affecting around 8% of children in the EU. Intuitively, you might not list apples as causing allergic reactions.
Living with covid-19 will need a testing transformation
As future covid-19 prevalence varies across time, health authorities must revolutionise testing to see if people are infected.
Are we able to detect all coronavirus variants?
Viruses do not evolve with the purpose of being more or less infectious or dangerous: it is just natural selection at work. New random variants occur continuously and most of them are neutral or make the virus less infectious.
Challenging Darwin: an ‘evolution machine’ for biomolecules
Darwin would be puzzled. He described natural selection as a slow process, selecting for the most suited organisms to a given environment.
Bacterial BioArt
Around 700,000 people are killed by antibiotic resistant infections in the world every year, estimates say. Antimicrobials are increasingly overused and misused, while some organisms are becoming more resistant to antibiotics.
Renewed hope for gene therapy in rare disease
Between 30 and 40 million people in Europe suffer from rare diseases —many of them children. As most of these diseases have genetic origins, gene therapy is a major hope for their future cure .
Secrets of youth, based on prevention
We age in two ways. There is the ageing we count by clock and calendar. And then there is biological ageing. The latter is written into our genes. But, it is also influenced by our lifestyle and history.
Ana Valdes – Twins studies to identify the molecular cause of ageing
What makes us age biologically? We have always been intrigued by this question. Yet, it remains a fundamental research challenge. Now, the EU-funded project, EurHEALTHAgeing , aims to draw together studies of early development with those on longevity and ageing.
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